Photodynamic therapy (PDT) is an attractive invasive method for cancer treatment. Therefore, novel therapies are needed to reduce the mortality rate and improve the life quality of the patient. Traditional therapies such as surgery, radiotherapy and chemotherapy have led to great success in clinical control, but accompanied by serious side effects. In recent years, there have been significant developments in the treatment of cancer. As a result, it is seen that SPDT is a combination which has enhanced the therapeutic outcome. Also apoptosis measurement data shows that the sensitizers ( 1a, 1b) would produce much better effects by combination sonodynamic and photodynamic therapies, especially the measurement of apoptotic cells in complex 2a reached 95% after SPDT therapy. According to MTT results, the sensitizers were showed quite efficiency for sonodynamic, photodynamic and sonophotodynamic therapies and decreased cell viability when compared with control group. For this purpose, the cells were incubated with various concentrations of chemicals and subjected to ultrasound and/or light irradiation. Then, the effects of sonodynamic, photodynamic and sonophotodynamic on these sensitizers were examined in vitro on prostate cancer using PC3 cells. In this study, new water soluble sensitizers with the different properties of linker heteroatom (O or S) were synthesized, characterized and analyzed their photophysicochemical properties. To the best of our knowledge, this paper is the first study in the literature to calculate the photochemical properties of synthesized molecules and compare the results of photodynamic, sonodynamic and sonophotodynamic therapies on prostate cancer cells. Although it is known that SPDT therapy has improved potential therapeutic result, the development of this method by working with different sensitizers has been lacking in the literature. Sonophotodynamic therapy (SPDT), a combination of photodynamic therapy (PDT) and sonodynamic therapy (SDT), is a new and promising method for the treatment of cancer cells. Even if you don't go all-in on this particular genre, you can use its core theory to make your leading lines more impactful.In this study, novel silicon phthalocyanines complexes have been synthesized, characterized and compared their antitumor efficiency of photodynamic, sonodynamic, sonophotodynamic on prostate cancer cells. Minimalist photography has become more popular in the 21st century, and for a good reason. Limit the Number of Subjects in Your Shots Figure out what you like and don't like, and then double down on what interests you. For example, your laptop's charging cable is a leading line to the plug.Įxamples of regular leading lines you can use include:Īgain, practicing is the best way to find which ones work best for you. In almost every surrounding, you'll find plenty of leading lines that you might not have even thought of. You can use the technique in numerous settings, regardless of whether your preference is urban or nature photography. If you don't want to use a drone for your photography, don't worry you can still make the most of leading lines in your photos on the ground. In some cases, it might be forbidden do your research beforehand and always respect the rules. If you choose to use a drone for leading lines in photography, remember that laws on flying these gadgets differ by region. But doing so is trickier than it seems you need to consider several factors that only become more apparent with higher levels of experience. Evoke Emotions in Your Photosįor many photographers, the ultimate goal with their images is to evoke emotions. Related: Looking to Improve Your Landscape Photography? Check Out These Tips 3. This is a particularly useful way to make your images stand out in landscape photography, but it also works for numerous other genres. Leading lines can help you achieve the above by putting the primary subject of your picture in the background. In many cases, you'll find a foreground, middle, and background. One thing that many of the best pictures have in common is depth. But as anyone that does this craft regularly quickly finds out, there's a lot more to creating the perfect image. Add Depth to Your Imagesįrom the outside looking in, it's easy to think that photography is as simple as pointing your camera at something and hoping for the best. As a result, your work will become more impactful and memorable with more people. When you use leading lines in your photos, you'll show the viewer exactly what you want them to look at.
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